信阳水牛肌纤维类型调控相关基因组织表达及分化时序研究

doi:10.19543/j.cnki.1673-4556.20260416.001

中国畜禽种业 ›› 2026, Vol. 22 ›› Issue (5): 32-42.doi: 10.19543/j.cnki.1673-4556.20260416.001cstr: 32418.14.j.cnki.1673-4556.20260416.001

所属专题：功能基因组学

信阳水牛肌纤维类型调控相关基因组织表达及分化时序研究

张潇戈¹(), 周艳朵², 李建彰¹, 马路平¹, 李军¹, 郝瑞杰³, 张子敬⁴, 马云⁵, 张天留⁶, 梁成成¹()

^1. 信阳农林学院动物科技学院，河南信阳 464000
^2. 信阳农林学院农学院，河南信阳 464000
^3. 信阳师范大学生命科学学院，河南信阳 464000
^4. 河南省农业科学院畜牧兽医研究所，河南郑州 450000
^5. 宁夏大学动物科技学院，宁夏银川 750000
^6. 河南农业大学动物科技学院，河南郑州 450000

收稿日期:2025-11-26 出版日期:2026-03-26 发布日期:2026-06-17
通讯作者: 梁成成 E-mail:OnlyIvan2435@163.com;lcc20151120@xyafu.edu.cn

作者简介:

张潇戈（2003—），女，河南郑州人，研究方向：反刍动物健康养殖，E-mail：OnlyIvan2435@163.com。

张潇戈，信阳农林学院动物科技学院，本科生，参与项目有河南省自然科学基金青年基金项目（252300423641）、河南省大学生创新创业训练计划（202511326001）以及信阳农林学院本科生科研训练项目（URPDK202501），曾获校三好学生，校优秀团员，校极优秀学生组织干部等荣誉。

梁成成，农学博士，信阳农林学院校聘副教授，主要研究方向水牛分子育种与健康养殖；兼任中国农学会秸秆资源综合利用分会理事、河南省“科技副总”、《中国畜禽种业》青年编委，获校级及以上荣誉9项；主持校级以上项目2项，参与省部级及以上课题4项；近5年累计发表各类论文31篇，获国家专利1项，参与制定地方标准1项，在信阳水牛研究领域形成扎实科研基础与系列成果。

基金资助:
河南省自然科学基金青年基金(252300423641); 河南省大学生创新创业训练计划(202511326001); 信阳农林学院本科生科研训练项目(URPDK202501)

Tissue expression and differentiation characteristics of genes regulating muscle fiber types in Xinyang buffalo

Xiaoge Zhang¹(), Yanduo Zhou², Jianzhang Li¹, Luping Ma¹, Jun Li¹, Ruijie Hao³, Zijing Zhang⁴, Yun Ma⁵, Tianliu Zhang⁶, Chengcheng Liang¹()

^1. College of Animal Science and Technology, Xinyang Agricultural and Forestry University, Xinyang, 464000, Henan
^2. College of Agronomy, Xinyang Agricultural and Forestry University, Xinyang, 464000, Henan
^3. College of Life Sciences, Xinyang Normal University, Xinyang, 464000, Henan
^4. Institute of Animal Husbandry and Veterinary Medicine, Henan Academy of Agricultural Sciences, Zhengzhou, 450000, Henan
^5. College of Animal Science and Technology, Ningxia University, Yinchuan, 750000, Ningxia
^6. College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450000, Henan

Received:2025-11-26 Online:2026-03-26 Published:2026-06-17
Contact: Chengcheng Liang E-mail:OnlyIvan2435@163.com;lcc20151120@xyafu.edu.cn

摘要/Abstract

摘要：

目的本研究旨在解析信阳水牛中与慢肌纤维向快肌纤维转化相关的肌肉因子MSTN、BDNF和DKK3的功能及其对肉质特性的影响，以期为信阳水牛品种改良提供参考。方法根据相关文献选取MSTN、BDNF、DKK3三个肌纤维因子，利用NCBI下载其氨基酸序列，利用MEME进行结构域预测，利用在线软件STRING分析蛋白互作情况，对其进行生物信息学分析。采集3头36月龄公牛的肝脏、脾脏、肺脏、肾脏、心脏、前腿肌、后腿肌、背最长肌、皮下肌、大肠、小肠等11种组织同时进行组织表达谱分析。采集1头1日龄新生牛的背最长肌，进行分离培养，诱导其分化并进行时序表达。结果生物学信息学分析显示，MSTN基因编码的蛋白质含有TGF-β信号通路相关结构域，主要在骨骼肌组织中高表达。BDNF基因编码的蛋白质含有神经营养因子相关结构域，主要在神经相关组织和骨骼肌中高表达。DKK3基因编码的蛋白质含有Wnt信号通路相关结构域，主要在脂肪和肝脏组织中高表达。GO和KEGG分析进一步表明，这些基因分别富集于TGF-β信号通路、神经营养因子信号通路和Wnt信号通路。时序分化结果表明，MSTN在分化前期表达上调，随后快速下调；BDNF基因表达量呈逐渐上升的趋势，在分化晚期再次被激活上调；DKK3在原代成肌细胞分化过程中不表达。结论以上结果表明MSTN、BDNF、DKK3基因表达与水牛肌纤维的形成存在关联。

关键词: 信阳水牛, MSTN, BDNF, DKK3, 生物信息学分析, 组织表达

Abstract:

Objective To elucidate the functions of MSTN, BDNF, and DKK3 genes associated with slow-to-fast muscle fiber conversion in Xinyang buffalo and their effects on meat quality characteristics, in order to provide reference for the improvement of Xinyang buffalo breeds. Method Three muscle fiber-related genes (MSTN, BDNF, DKK3) were selected from relevant literature. Their amino acid sequences were downloaded from NCBI, domain prediction was performed using MEME, and protein interaction analysis was conducted through the online software STRING for bioinformatics evaluation. Tissue samples from three 36-month-old bulls (Liver, spleen, lung, kidney, heart, foreleg muscle, hindleg muscle, longissimus dorsi muscle, subcutaneous muscle, large intestine, small intestine) were collected for tissue expression profiling. Collect the longissimus dorsi muscle from a 1-day-old newborn calf, isolate and culture the primary cells, induce their differentiation, and analyze time-course gene expression. Result Bioinformatics analysis reveals that the protein encoded by the MSTN gene contains domains associated with the TGF-β signaling pathway and is predominantly highly expressed in skeletal muscle tissue. The protein encoded by the BDNF gene possesses domains related to neurotrophic factors and is primarily highly expressed in neural tissues and skeletal muscle. The protein encoded by the DKK3 gene contains domains associated with the Wnt signaling pathway and is mainly highly expressed in adipose and liver tissues. GO and KEGG analyses further indicated that these genes were respectively enriched in the TGF-β signaling pathway, neurotrophic factor signaling pathway, and Wnt signaling pathway. The temporal differentiation results showed that the expression of MSTN was upregulated in the early stage of differentiation and then rapidly downregulated; the expression level of the BDNF gene exhibited a gradual upward trend and was reactivated and upregulated at the late differentiation stage; DKK3 was not expressed during the differentiation of primary myoblasts. Conclusion These results indicate that the expression of MSTN, BDNF, and DKK3 genes is associated with the formation of muscle fibers in buffalo.

Key words: Xinyang buffalo, MSTN, BDNF, DKK3, Bioinformatics analysis, Tissue expression

中图分类号:

S823

张潇戈, 周艳朵, 李建彰, 马路平, 李军, 郝瑞杰, 张子敬, 马云, 张天留, 梁成成. 信阳水牛肌纤维类型调控相关基因组织表达及分化时序研究[J]. 中国畜禽种业, 2026, 22(5): 32-42.

Xiaoge Zhang, Yanduo Zhou, Jianzhang Li, Luping Ma, Jun Li, Ruijie Hao, Zijing Zhang, Yun Ma, Tianliu Zhang, Chengcheng Liang. Tissue expression and differentiation characteristics of genes regulating muscle fiber types in Xinyang buffalo[J]. Chinese Livestock and Poultry Breeding, 2026, 22(5): 32-42.

图/表 8

表1

图1

图2

图3

表2

表3

蛋白互作网络GO富集分析"

项目 Items	基因 Genes	项目ID Term ID	项目描述 Term description	基因数量 Gene count	错误率FDR	基因 Genes
细胞组分 Cellular component	MSTN	GO: 0048179	激活素受体复合体	4	1.99E-08	TGFBR1, ACVR2A, ACVR1B, ACVR2B
	BDNF	GO: 0045202	突触	5	0.0174	BDNF, NGFR, NTRK2, NTF4, NGF
	BDNF	GO: 0120025	质膜界定的细胞突起	6	0.0174	CNTF, BDNF, NTRK2, NTF4, NGF, GFAP
	DKK3	GO: 0005576	细胞外区域	8	0.0014	DKK3, FRZB, DKK2, WIF1, SFRP4, SFRP2, SFRP1, DKK1
分子功能 Molecular function	MSTN	GO: 0048179	激活素受体复合体	4	1.99E-08	TGFBR1, ACVR2A, ACVR1B, ACVR2B
	MSTN	GO: 0048185	激活素结合	6	2.20E-13	FST, TGFBR1, ACVR2A, ACVR1B, FSTL3, ACVR2B
	BDNF	GO: 0017002	激活素受体活性	4	4.83E-08	TGFBR1, ACVR2A, ACVR1B, ACVR2B
	DKK3	GO: 0017147	Wnt蛋白结合	5	1.02E-08	LRP5, FRZB, SFRP4, SFRP2, SFRP1
		GO: 0005102	信号受体结合	6	0.0105	DKK3, DKK2, WIF1, SFRP2, SFRP1, DKK1
		GO: 0005515	蛋白质结合	10	0.021	DKK3, LRP5, FRZB, DKK2, WIF1, SFRP4, CTNNB1, SFRP2, SFRP1, DKK1
		GO: 0030545	信号受体调节活性	4	0.0462	DKK3, DKK2, SFRP2, DKK1
		GO:0017147	Wnt蛋白结合	5	1.02E-08	LRP5, FRZB, SFRP4, SFRP2, SFRP1
生物学过程Biological process	MSTN	GO: 0032925	激活素受体信号通路的调控	5	6.04E-09	FST, SMAD2, ACVR2A, ACVR1B, FSTL3
		GO: 0007178	跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路	7	7.99E-09	FST, MSTN, SMAD2, TGFBR1, ACVR2A, ACVR1B, ACVR2B
		GO: 0045595	细胞分化调控	10	7.99E-09	MYOD1, FST, MYOG, MSTN, SMAD2, TGFBR1, ACVR2A, MYF5, ACVR1B, FSTL3
	BDNF	GO: 0038179	神经营养因子信号通路	5	4.78E-09	BDNF, NTRK2, NTF4, NGF, SORT1
	DKK3	GO: 0090090	典型Wnt信号通路的负调控	9	4.90E-15	DKK3, FRZB, DKK2, SFRP4, CTNNB1, KREMEN1, SFRP2, SFRP1, DKK1
	DKK3	GO: 0045597	细胞分化的正调控	7	4.31E-06	LRP5, FRZB, WIF1, SFRP4, CTNNB1, SFRP2, SFRP1

表3

图4

图5

参考文献 35

[1]	万根, 王也, 杨晓雪, 等. 不同品种河流型水牛及其杂交品种肠道微生物群落分析[J]. 江西农业大学学报, 2025, 47(4): 1049-1061.
	WAN G, WANG Y, YANG X X, et al. Analysis of gut microbial communities in different breeds of riverine buffaloes and their hybrids[J]. Acta Agriculturae Universitatis Jiangxiensis (Natural Sciences Edition), 2025, 47(4): 1049-1061.
[2]	郭荣珍. 不同质量控制方式对中国沼泽型水牛肉品质的影响[D]. 柳州: 广西科技大学, 2022.
	GUO R Z. Effects of different quality control methods on meat quality of Chinese swamp buffalo[D]. Liuzhou: Guangxi Univer-sity of Science and Technology, 2022.
[3]	马云, 左春生, 王启钊, 等. 信阳水牛种质资源研究[J]. 中国草食动物, 2009, 29(2): 64-67.
	MA Y, ZUO C S, WANG Q Z, et al. Study on Xinyang buffalo germplasm resources[J]. China Herbivores, 2009, 29(2): 64-67.
[4]	梁成成, 周艳朵, 李军, 等. 信阳水牛品种资源发展现状与建议[J]. 中国畜禽种业, 2025, 21(9): 116-125.
	LIANG C C, ZHOU Y D, LI J, et al. Current status and suggestions on the breed resources and development of Xinyang buffalo[J]. The Chinese Livestock and Poultry Breeding, 2025, 21(9): 116-125.
[5]	谷兴亮, 关诗宇, 沈宏旭, 等. 草原红牛不同部位肌肉组织形态学研究[J]. 黑龙江畜牧兽医, 2024(23): 45-49, 124-125.
	GU X L, GUAN S Y, SHEN H X, et al. Study on muscle morphology of different parts of prairie red cattle[J]. Heilongjiang Animal Science and Veterinary Medicine, 2024(23): 45-49, 124-125.
[6]	罗敬, 雷开英, 石嵩, 等. 顺式调控元件在动物骨骼肌肌纤维类型决定和转化中的作用[J]. 遗传, 2025, 47(4): 437-447.
	LUO J, LEI K Y, SHI S, et al. The role of cis-regulatory elements in the determination and transformation of muscle fiber type in animal skeletal muscles[J]. Hereditas, 2025, 47(4): 437-447.
[7]	黄博宇, 张孜怡, 庞卫军. 肌肉因子对骨骼肌纤维类型转化的作用及机制研究进展[J]. 生物工程学报, 2024, 40(12): 4365-4381.
	HUANG B Y, ZHANG Z Y, PANG W J. Progress and prospects of the effects and mechanisms of myokines in regulating fiber type transition of skeletal muscle[J]. Chinese Journal of Biotechnology, 2024, 40(12): 4365-4381.
[8]	蔡树东, 李文, 周斐然, 等. 肉牛肌肉生长抑制素基因研究进展[J]. 中国草食动物科学, 2023, 43(4): 59-63.
	CAI S D, LI W, ZHOU F R, et al. Research progress of beef cattle myostatin gene[J]. China Herbivore Science, 2023, 43(4): 59-63.
[9]	董诗琳, 张梦帆, 李耀东. MSTN基因在动物生产中的研究进展[J]. 现代畜牧兽医, 2020(12): 61-64.
	DONG S L, ZHANG M F, LI Y D. Research progress of MSTN gene in animal production[J]. Modern Journal of Animal Husbandry and Veterinary Medicine, 2020(12): 61-64.
[10]	陈渝鸣, 段皓月, 黄蔚, 等. 三江牛MSTN基因多态性与体尺性状的关联分析研究[J]. 中国畜禽种业, 2025, 21(9): 39-48.
	CHEN Y M, DUAN H Y, HUANG W, et al. Polymorphisms of MSTN gene and its correlation with body size traits in Sanjiang cattle[J]. The Chinese Livestock and Poultry Breeding, 2025, 21(9): 39-48.
[11]	王鑫, 高广琦, 魏著英, 等. 杂交F1代myostatin基因编辑肉牛的肉质特性分析[J]. 中国牛业科学, 2018, 44(3): 1-7.
	WANG X, GAO G Q, WEI Z Y, et al. Meat quality analysis of crossbred cattle with myostatin gene editing[J]. China Cattle Science, 2018, 44(3): 1-7.
[12]	YUE Y, YANG H J, LI C, et al. Beneficial effects of traditional fermented soybean sauce (kanjang) on memory function, body water, and glucose metabolism: roles of gut microbiota and neuroinflammation[J]. Nutrients, 2025, 17(10): 1617.
[13]	DELEZIE J, WEIHRAUCH M, MAIER G, et al. BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle[J]. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(32): 16111-16120.
[14]	ZHANG Z, WANG B L, FEI A H. BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice[J]. Archives of Medical Science, 2019, 15(1): 214-222.
[15]	郭进磊. 中国三个黄牛品种DKK3基因遗传多态性研究[D]. 杨凌: 西北农林科技大学, 2012.
	GUO J L. Genetic analysis of DKK3 gene of three Chinese yellow cattle breeds[D]. Yangling: Northwest A & F University, 2012.
[16]	张凤, 陈明新. 肉牛DKK3基因3’UTR双荧光素酶报告质粒构建及与miR-25的靶向验证[J]. 中国畜牧杂志, 2022, 58(6): 135-140.
	ZHANG F, CHEN M X. Construction of 3'UTR dual luciferase reporter plasmid of beef DKK3 gene and its targeting verification with miR-25[J]. Chinese Journal of Animal Science, 2022, 58(6): 135-140.
[17]	ZHANG F M, WU H F, WANG K F, et al. Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity[J]. Cell Death & Disease, 2024, 15: 459.
[18]	陈瑞. 家兔Prrx基因家族: 克隆分析、原核表达及表达图谱[D]. 成都: 西南民族大学, 2015.
	Chen R. Prrx gene family in rabbits: cloning and analysis, prokaryotic expression, and expression profiling[D]. Chengdu: Southwest Minzu University, 2015.
[19]	曾建红, 李丛艳, 郭志强, 等. 蜀兴1号肉兔和伊拉兔生产性能及MSTN、Myf5和MyoG基因的表达[J]. 江苏农业科学, 2024, 52(8): 151-157.
	ZENG J H, LI C Y, GUO Z Q, et al. Production performance and MSTN Myf5, MyoG gene expression of Shuxing No.1 meat rabbit and Ira rabbit[J]. Jiangsu Agricultural Sciences, 2024, 52(8): 151-157.
[20]	杨漫漫. 牛MyoG、MSTN基因遗传分析及miR-143载体构建[D]. 合肥: 安徽农业大学, 2014.
	YANG M M. Genetic analysis of bovine MyoG and MSTN genes and construction of miR-143 vector[D]. Hefei: Anhui Agri-cultural University, 2014.
[21]	张润锋. 牛MRF家族、MSTN、GHRH和GHR基因变异及其与生长性状的相关分析[D]. 杨凌: 西北农林科技大学, 2007.
	Zhang, R F. Genetic variants of bovine MRF family, MSTN, GHRH, and GHR genes and their correlation with growth traits[D]. Yangling: Northwest A&F University, 2007.
[22]	王文涛, 胡健, 张福平. 赤水乌骨鸡Myf5基因SNPs与周龄体重的关联性分析[J]. 贵州畜牧兽医, 2024, 48(2): 15-18.
	WANG W T, HU J, ZHANG F P. Association analysis between Myf5 gene SNPs and yearling weight in Chishui black-bone chickens[J]. Guizhou Journal of Animal Husbandry & Veteri-nary Medicine, 2024, 48(2): 15-18.
[23]	张雄, 张勇, 陈祥, 等. 猪肌分化因子1基因启动子区多态性及生物信息学研究[J]. 中国畜牧兽医, 2016, 43(5): 1308-1315.
	ZHANG X, ZHANG Y, CHEN X, et al. Study on polymorphisms and bioinformatics of MyoD1 gene promoter region in pig[J]. China Animal Husbandry & Veterinary Medicine, 2016, 43(5): 1308-1315.
[24]	高泽仁, 潘鹏丞, 徐文文, 等. 陆川猪MyoD1基因克隆及组织表达分析[J]. 华北农学报, 2024, 39(2): 168-173.
	GAO Z R, PAN P C, XU W W, et al. Cloning and tissue expression analysis of MyoD1 gene in Luchuan pig[J]. Acta Agriculturae Boreali-Sinica, 2024, 39(2): 168-173.
[25]	祖玲玲, 姚力丹, 依明·苏莱曼, 等. MSTN基因在1～6月龄哈萨克羔羊肌肉组织中表达量及其与生长指标相关性分析[J]. 中国畜牧兽医, 2016, 43(2): 487-492.
	ZU L L, YAO L D, YIMING S L M, et al. Expression levels of MSTNgene in muscle tissues and its association with growth indexes in 1-6 months old Kazak lamb[J]. China Animal Husbandry & Veterinary Medicine, 2016, 43(2): 487-492.
[26]	易康乐. Figla和BDNF对猪和牛卵母细胞及早期胚胎生长发育的影响[D]. 长春: 吉林大学, 2008.
	YI K L. Effects of Figla and BDNF on the growth and development of oocytes and early embryos in pigs and cattle[D]. Changchun: Jilin University, 2008.
[27]	魏金销, 张月, 方芳, 等. miR-10b和BDNF对山羊卵巢颗粒细胞活性的影响[J]. 家畜生态学报, 2018, 39(12): 44-50.
	WEI J X, ZHANG Y, FANG F, et al. Effect of miR-10b and BDNF on activity of ovarian granulosa cells in goats[J]. Acta Ecologae Animalis Domastici, 2018, 39(12): 44-50.
[28]	YOO K, JO Y W, YOO T, et al. Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis[J]. eLife, 2024, 13: RP97662.
[29]	刘琼. BDNF、GDNF对新生大鼠海马神经干细胞增殖和分化的影响[C]. //细胞·生命·健康——第十一届中国细胞生物学学术大会暨2009西安细胞生物学国际会议论文集. 西安, 2009: 293.
	Liu Q. Effects of BDNF and GDNF on the proliferation and differentiation of neural stem cells in the hippocampus of neonatal rats[C]. //Cell·Life·Health—Proceedings of the 11th Chinese Society for Cell Biology Academic Conference & 2009 Xi’an International Conference on Cell Biology, 2009: 293.
[30]	XU S, GU L L, BAO B H, et al. Mechanistic insights into the neuroprotective effects of low-intensity transcranial ultrasound stimulation in post-cardiac arrest brain injury: modulation of the Piezo1-Dkk3/PI3K-Akt pathway[J]. Brain, Behavior, and Immunity, 2025, 127: 341-357.
[31]	杜凤娇, 刘晓淋, 吴柱连, 等. 水牛脑源性神经营养因子基因克隆、序列分析及其在不同组织中的表达研究[J]. 中国畜牧兽医, 2015, 42(4): 830-837.
	DU F J, LIU X L, WU Z L, et al. Cloning and sequence analysis of buffalo BDNF gene and investigation of its expression pattern in different tissues[J]. China Animal Husbandry & Veterinary Medicine, 2015, 42(4): 830-837.
[32]	FERRARI N, RANFTL R, CHICHEROVA I, et al. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts[J]. Nature Com-munications, 2019, 10: 130.
[33]	POOREBRAHIM M, SADEGHI S, RAHIMI H, et al. Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency[J]. PLoS One, 2017, 12(2): e0172217.
[34]	FUENTES L A ROA, BLOEMEN M, CARELS C E, et al. Retinoic acid effects on in vitro palatal fusion and WNT signaling[J]. European Journal of Oral Sciences, 2022, 130(6): e12899.
[35]	NIEHRS C. Function and biological roles of the Dickkopf family of Wnt modulators[J]. Oncogene, 2006, 25(57): 7469-7481.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

基因Genes	引物序列（5'-3'）Primer sequence	产物长度Product length/bp	退火温度Annealing temperature/℃
MSTN-F	CATTACCATGCCCACGGAGTCTG	149	63.6
MSTN-R	TCGCAGGAGTCTTGACAGGTCTC	149	63.6
BDNF-F	AACTCCCAGTGCCGAACTACCC	80	64.1
BDNF-R	ATGAACCGCCAGCCAATACGC	80	64.1
DKK3-F	TCGTCCTCTCGGCAGTGTTACTC	148	63.6
DKK3-R	ACTCGGGCAAGCAAGATGACATC	148	63.6
β- actin-F	CATCCTGACCCTCAAGTA	91	52.3
β -actin-R	CTCGTTGTAGAAGGTGTG	91	52.3

核心蛋白 Core protein	通路ID Term ID	通路描述 Term description	基因数量 Gene count	错误率 FDR	基因 Genes
MSTN	bta04350	TGF-β信号通路	6	7.56E-10	FST, SMAD2, TGFBR1, ACVR2A, ACVR1B, ACVR2B
	bta04550	调节干细胞多能性	5	6.67E-07	SMAD2, ACVR2A, MYF5, ACVR1B, ACVR2B
	bta04060	细胞因子-受体相互作用	5	1.62E-05	MSTN, TGFBR1, ACVR2A, ACVR1B, ACVR2B
BDNF	bta04722	神经营养因子	6	2.24E-09	BDNF, NGFR, NTRK2, NTF4, NGF, SORT1
	bta04151	PI3K-Akt信号通路	6	9.36E-07	BDNF, IL6, NGFR, NTRK2, NTF4, NGF
	bta04014	Ras信号通路	5	5.85E-06	BDNF, NGFR, NTRK2, NTF4, NGF
	bta04010	MAPK信号通路	5	1.03E-05	BDNF, NGFR, NTRK2, NTF4, NGF
DKK3	bta04310	Wnt信号通路	7	6.33E-11	LRP5, DKK2, SFRP4, CTNNB1, SFRP2, SFRP1, DKK1

信阳水牛肌纤维类型调控相关基因组织表达及分化时序研究

Tissue expression and differentiation characteristics of genes regulating muscle fiber types in Xinyang buffalo

RichHTML

PDF (PC)

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 35

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	昝林森. 国际肉牛育种进展对我国地方黄牛遗传改良的启示[J]. 中国畜禽种业, 2026, 22(8): 10-18.
[2]	曹晓瑶, 李姣, 王亭, 熊兰玲, 蔡向庭, 冯思远, 王泽昭, 郑彩宏, 陈燕, 张路培, 高雪, 高会江, 朱波, 李俊雅. 中国肉牛遗传改良研究进展与未来展望：从“追赶”到“创新”的种业振兴之路[J]. 中国畜禽种业, 2026, 22(8): 19-31.
[3]	喇永富, 梁春年. 牦牛繁育关键技术创新应用、挑战及对策[J]. 中国畜禽种业, 2026, 22(8): 32-41.
[4]	鲍迪, 孙铭, 秦立红. 吉林省肉牛遗传改良研究进展[J]. 中国畜禽种业, 2026, 22(8): 42-47.
[5]	王宏浩, 刘彦杰, 张元庆. 山西肉牛育种：聚焦“太行云牛”的遗传改良实践[J]. 中国畜禽种业, 2026, 22(8): 48-53.
[6]	彭朋, 刘廷玉, 赵慧峰, 赵博伟, 李素霞, 徐华, 李树静, 王昆. 河北省肉牛遗传改良现状、存在的问题及发展建议[J]. 中国畜禽种业, 2026, 22(8): 54-60.
[7]	冯豆, 邓红雨, 王利宁, 姚嘉伦, 贺磊, 全清华, 贺倩倩, 张震. 河南省肉牛发展现状及策略研究[J]. 中国畜禽种业, 2026, 22(8): 61-67.
[8]	索朗曲吉, 普布占堆, 李斌, 斯朗旺姆, 温东旭, 赵丽, 嘎玛央宗, 次仁罗布, 陈晓英, 尼玛, 西热强马, 达瓦, 扎西坚参, 拉巴次仁, 张楠, 马毅, 陈宁博. 藏青牛遗传资源现状及种质特性鉴定研究[J]. 中国畜禽种业, 2026, 22(8): 68-78.
[9]	杨武才, 杨本顺, 刘文杰, 周正海, 谭建兵, 孔贤亚, 昝林森. 中国黄牛保种、选育及产业化利用现状与发展建议[J]. 中国畜禽种业, 2026, 22(8): 79-89.
[10]	张科举, 王香南, 董改新, 吕志远, 张子敬, 刘贤, 吕世杰, 林凤鹏, 祁兴山, 屈博文, 王二耀, 祁兴磊. “中原牛”种公牛精液生产性能及母牛繁殖性能[J]. 中国畜禽种业, 2026, 22(8): 90-95.
[11]	李静, 杨术环, 尤佳, 金双勇. 辽育白牛选育研究进展[J]. 中国畜禽种业, 2026, 22(8): 96-102.
[12]	陈伟生, 李立望, 彭华. 我国肉牛业发展现状、历史演进与未来发展路径研究[J]. 中国畜禽种业, 2026, 22(6): 10-17.
[13]	陈宏. 中国地方黄牛品种的选育与杂交利用[J]. 中国畜禽种业, 2026, 22(6): 18-24.
[14]	缪立生, 汪聪勇, 曹阳, 赵玉民. 肉牛种业发展及遗传改良路径[J]. 中国畜禽种业, 2026, 22(6): 25-30.
[15]	王海, 余道宁, 张纯, 褚倩倩, 赵军均, 张岱阳, 汪聪勇. 华西牛育种技术创新与产业化推广研究[J]. 中国畜禽种业, 2026, 22(6): 38-44.