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Chinese Livestock and Poultry Breeding ›› 2026, Vol. 22 ›› Issue (5): 108-115.doi: 10.19543/j.cnki.1673-4556.20260427.001cstr: 32418.14.j.cnki.1673-4556.20260427.001

• Animal Genetics and Breeding • Previous Articles     Next Articles

Research progress on genetic diversity of coat color in livestock genetic breeding

Tiantian Wang1(), Jiahao Shao1, Wenmiao Duan1, Jianing Lu1, Jianhua Zeng2, Xiaohong Liu3,4, Xiaolong Yuan1,4()   

  1. 1.National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong
    2.Guangdong Yihao Indigenous Pig Research Institute Co. Ltd, Zhanjiang, 524000, Guangdong
    3.School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, Guangdong
    4.National Pig Technology Innovation Center, Chongqing, 402460
  • Received:2025-11-27 Online:2026-03-26 Published:2026-06-17
  • Contact: Xiaohong Liu, Xiaolong Yuan E-mail:wtt661018@163.com;yxl@scau.edu.cn

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Abstract:

With the development of gene editing and molecular breeding technology, the application value of coat color genetic diversity in livestock genetic breeding has become increasingly prominent. It is not only a significant apparent feature of the variety, but also an intuitive genetic marker for judging the purity of the variety. In view of the different genes and genetic rules of coat color control in major livestock such as pigs, cattle and sheep, this paper reviewed the research progress of coat color inheritance in major livestock such as pigs, cattle and sheep, clarified the function and interaction regulation mechanism of key coat color genes, and sorted out the genetic rules of different coat color phenotypes. Studies have shown that the color of pigs, cattle and sheep is regulated by key genes such as MC1R, KIT, ASIP and TYR. Through dominant epistasis, recessive homozygosity, gene interaction and signal pathway differences, the synthesis of true melanin and brown melanin, the proliferation and differentiation of melanocytes and the spatial and temporal distribution of pigments are regulated, and finally a variety of hair color phenotypes such as white, black, red, spotted, brown and gray are formed. At the same time, the breeding examples of Jishen black pig, Chuanxiang black pig, Tianfu black pig, Liaodan black pig, Huaxi cattle, Ashdan yak, Tianhua mutton sheep, Dumeng sheep and Chubao black sheep are combined. The application path and practical effect of coat color in variety purification were analyzed in order to provide theoretical support and practical guidance for livestock genetic breeding.

Key words: Coat color, Traits, Livestock, Genotype, Genetic breeding

CLC Number: 

  • S81

Fig. 1

Schematic diagram of genes related to coat color in pigsNote: Pictures are drawn using BioRender. The following picture is the same."

Fig. 2

Schematic diagram of genes related to coat color in cattle"

Fig. 3

Schematic diagram of genes related to coat color in sheep"

[1] 郑浩. 巴里杂交猪和鲁莱黑猪毛色分离的遗传解析[D]. 南昌: 江西农业大学, 2019.
ZHENG H. Genetic analysis of hair color separation in barry Hybrid pigs and Lulai black pigs[D]. Nanchang: Jiangxi Agr-icultura University, 2019.
[2] MAO H R, REN J, DING N S, et al. Genetic variation within coat color genes of MC1R and ASIP in Chinese brownish red Tibetan pigs[J]. Animal Science Journal, 2010, 81(6): 630-634.
[3] KAWAGUCHI F, SHAKU A, SHAH MK, et al. Detection of MC1R Genetic Variants and Their Association with Coat Co-lor in Asian Goats. Animals (Basel) [J]. 2025, 15(14): 2026.
[4] SULTANA N, KHAN M K I, DAS A, et al. Expression of coat colour gene, MC1R in cattle[J]. Indian Journal of Animal Research, 2022: 7-11.
[5] ZHANG M Q, XU X, LUO S J. The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens)[J]. Animal Genetics, 2014, 45(5): 652-659.
[6] LIU X, PENG Y, ZHANG X, et al. Coloration in equine: overview of candidate genes associated with coat color phen-otypes[J]. Animals (Basel). 2024 14(12): 1802.
[7] 张建, 陈伟, 王慧, 等. 猪毛色遗传机制的研究进展[J]. 猪业科学, 2013, 30(1): 100-103.
ZHANG J, CHEN W, WANG H, et al. Research progress on genetic mechanism of pig coat color[J]. Swine Industry Science, 2013, 30(1): 100-103.
[8] MARKLUND S, KIJAS J, RODRIGUEZ-MARTINEZ H, et al. Molecular basis for the dominant white phenotype in the domestic pig[J]. Genome Research, 1998, 8(8): 826-833.
[9] KIJAS J M, WALES R, TÖRNSTEN A, et al. Melanocortin receptor 1 (MC1R) mutations and coat color in pigs[J]. Genetics, 1998, 150(3): 1177-1185.
[10] LIANG X Y, LAN J, XU M N, et al. Impact of KIT editing on coat pigmentation and fresh meat color in Yorkshire pigs[J]. The CRISPR Journal, 2022, 5(6): 825-842.
[11] 彭刚. 猪MC1R、ASIP、TYR、TYRP1和SLC45A2基因多态性及其与毛色相关性研究[D]. 武汉: 华中农业大学, 2019.
PENG G. Polymorphisms of MC1R, ASIP, TYR, TYRP1 and SLC45A2 genes in pigs and their correlation with coat co-lor[D]. Wuhan : Huazhong Agricultural University, 2019.
[12] 朱春凤, 冯永山. Agouti基因及其表达产物的结构与功能[J]. 黑龙江医药, 2012, 25(3): 401-402.
ZHU C F, FENG Y S. Structure and function of Agouti gene and its expression product[J]. Heilongjiang Medicine Journal, 2012, 25(3): 401-402.
[13] 李丽莎, 李祥龙. 动物毛色候选基因TYRP1的研究进展[J]. 河北科技师范学院学报, 2015, 29(4): 9-13.
LI L S, LI X L. Research progress of animal coat color candidate gene in tyrosinase related protein 1(TYRP1)[J]. Journal of Hebei Normal University of Science & Technology, 2015, 29(4): 9-13
[14] ZHONG H W, ZHANG J, TAN C, et al. Pig coat color manipulation by MC1R gene editing[J]. International Journal of Molecular Sciences, 2022, 23(18): 10356.
[15] SAUERMANN R, FANCOURT B, FAULKNER T, et al. Loss-of-function mutations in ASIP and MC1R are associated with coat colour variation in marsupials[J]. Biology Letters, 2025, 21(10): 20250302.
[16] JIVANJI S, WILKINSON E, TANG L, et al. Structural and epistatic regulatory variants cause hallmark white spotting in cattle[J]. Science Advances, 2025 14(46): 5913.
[17] AI H S, HUANG L S, REN J. Genetic diversity, linkage disequilibrium and selection signatures in Chinese and Western pigs revealed by genome-wide SNP markers[J]. PLoS One, 2013, 8(2): e56001.
[18] 舒鸣, 肖兵南, 陈铁桥. 牛毛色遗传的研究进展[J]. 中国牛业科学, 2008, 34(1): 15-17, 20.
SHU M, XIAO B N, CHEN T Q. Research progress on heredity of the coat color of cattle[J]. China Cattle Science, 2008, 34(1): 15-17, 20.
[19] LIANG D, ZHAO P J, SI J F, et al. Genomic analysis revealed a convergent evolution of LINE-1 in coat color: a case study in water buffaloes (Bubalus bubalis)[J]. Molecular Biology and Evolution, 2021, 38(3): 1122-1136.
[20] 郭敏, 张大山, 李祥龙. TYR基因及其与动物毛色关系的研究进展[J]. 黑龙江畜牧兽医, 2017(1): 83-85.
GUO M, ZHANG D S, LI X L. Research progress of TYR gene and its relationship with animal coat color[J]. Heilongjiang Animal Science and Veterinary Medicine, 2017(1): 83-85.
[21] SANTANA C J S, SANTOS ALVES J, PINTO L F B, et al. A deletion in the MC1R gene alters coat color in Guzerat cattle[J]. Animal Genetics, 2021, 52(6): 896-897
[22] HAUSER M, SIGNER-HASLER H, KÜTTEL L, et al. Identification of two new recessive MC1R alleles in red-coloured Evolèner cattle and other breeds[J]. Animal Genetics, 2022, 53(3): 427-435.
[23] ZHANG H Y, XU L, WANG J H, et al. PMEL as a candidate gene for coat color differentiation in Sibu yaks: genetic and functional insights[J]. Zoological Research, 2025, 46(6): 1363-1374.
[24] MAUDET C, TABERLET P. Holstein's milk detection in cheeses inferred from melanocortin receptor 1 (MC1R) gene polymorphism[J]. Journal of Dairy Science, 2002, 85(4): 707-715.
[25] JIVANJI S, WILKINSON E, TANG L J, et al. Structural and epistatic regulatory variants cause hallmark white spotting in cattle[J]. Science Advances, 2025, 11(46): eadt5913.
[26] 成进波. 产于雷州半岛的雷琼黄牛毛色遗传分析[J]. 现代农业科技, 2019(5): 202-204.
CHENG J B. Genetic analysis of coat color of Leiqiong yellow cattle produced in Leizhou Peninsula[J]. Modern Agricultural Science and Technology, 2019(5): 202-204.
[27] VOß K, BLAJ I, TETENS J L, et al. Roan coat color in livestock[J]. Animal Genetics, 2022, 53(5): 549-556.
[28] 孙晓燕, 付琳, 陈灿灿, 等. 绵羊毛色相关基因MC1R和ASIP的研究进展[J]. 黑龙江畜牧兽医, 2019(17): 41-44.
SUN X Y, FU L, CHEN C C, et al. Research advances in sheep coat color related genes MC1R and ASIP[J]. Heilongjiang Animal Science and Veterinary Medicine, 2019(17): 41-44.
[29] SAUERMANN R, FANCOURT B, FAULKNER T, et al. Loss-of-function mutations in ASIP and MC1R are associated with coat colour variation in marsupials[J]. Biology Letters, 2025, 21(10): 20250302.
[30] ZHU Z, HE J, JIA X, et al. microRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca (Lama pacos) skin melanocytes[J]. Domestic Animal Endocrinology, 2010, 38(3): 200-209.
[31] 邓雅迪, 张雪梅, 王旭光. 不同毛色ASIP基因编辑中国美利奴细毛羊皮肤组织中黑色素分布及ASIP蛋白的表达定位[J]. 黑龙江畜牧兽医, 2024(1): 17-22.
DENG Y D, ZHANG X M, WANG X G. The distribution of melanin and the expression and localization of ASIP protein in the skin tissue of different coat color ASIP gene editing Chinese Merino fine wool sheep[J]. Heilongjiang Animal Husbandry and Veterinary, 2024(1): 17-22.
[32] LEE Y N, BRANDAL S, NOEL P, et al. KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation[J]. Blood, 2011, 117(13): 3629-3640.
[33] 许冬梅, 赵园园, 朱芷葳, 等. 羊驼皮肤Scf基因的分子克隆、表达分析及组织学分布[J]. 中国生物化学与分子生物学报, 2020, 36(7): 832-840.
XU D M, ZHAO Y Y, ZHU Z W, et al. Molecular cloning, expression analysis and tissue distribution of scf gene in alpaca (vicugnapaco) skin[J]. Chinese Journal of Biochemistry and Molecular Biology, 2020, 36(7): 832-840.
[34] ZHANG X M, LI W R, LIU C X, et al. Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9[J]. Scientific Reports, 2017, 7: 8149.
[35] YAO L D, BAO A, HONG W J, et al. Transcriptome profiling analysis reveals key genes of different coat color in sheep skin[J]. PeerJ, 2019, 7: e8077.
[36] KAWAGUCHI F, SHAKU A, SHAH M K, et al. Detection of MC1R genetic variants and their association with coat color in Asian goats[J]. Animals, 2025, 15(14): 2026.
[37] YANG S L, MAO H M, SHU W, et al. Melanin traits of Yunnan black bone sheep and TYR gene polymorphism[J]. Hereditas, 2006, 28(3): 291-298.
[38] 张军杰. 山羊c-KIT和SCF基因在皮肤中的表达及与毛色关系研究[D]. 保定: 河北农业大学, 2014.
ZHANG J J. Expression of c-KIT and SCF genes in goat skin and their relationship with hair color[D]. Baoding: Hebei Agricultural University, 2014.
[39] YANG G L, FU D L, LANG X, et al. Mutations in MC1R gene determine black coat color phenotype in Chinese sheep[J]. The Scientific World Journal, 2013, 2013(1): 675382.
[40] DENG S H, GAO J, REN J, et al. Studies of the relationship of melanocortin receptor 1(MC1R) gene with coat color phenotype in pigs[J]. Acta Genetica Sinica, 2003, 30(10): 949-954.
[41] 常乐, 孙延纯, 朱德富. 精气神山黑猪的培育[J]. 中国猪业, 2013, 8(S1): 64-65.
CHANG L, SUN Y C, ZHU D F. Cultivation of Shenshan black pig with vitality[J]. China Swine Industry, 2013, 8(S1): 64-65.
[42] 杨雪梅, 杨跃奎, 曾凯, 等. 川乡黑猪新品种培育[J]. 中国畜禽种业, 2025, 21(1): 49-56.
YANG X M, YANG Y K, ZENG K, et al. Cultivation of Chuanxiang black swine[J]. The Chinese Livestock and Poultry Breeding, 2025, 21(1): 49-56.
[43] 罗成刚, 袁蓉, 李育晶, 等. 我国地方品种成华猪遗传资源保护与利用现状分析[J]. 中国畜牧杂志, 2022, 58(8): 313-316.
LUO C G, YUAN R, LI Y J, et al. Analysis on the present situation of protection and utilization of genetic resources of Chenghua pig, a local breed in China[J]. Chinese Journal of Animal Science, 2022, 58(8): 313-316.
[44] 徐广鹤, 周明君, 时吉刚. 辽丹黑猪的毛色遗传分析[J]. 猪业科学, 2023, 40(5): 104-105.
XU G H, ZHOU M J, SHI J G. Genetic analysis of coat color of Liaodan black pig[J]. Swine Industry Science, 2023, 40(5): 104-105.
[45] 张天留, 王泽昭, 朱波, 等. 华西牛新品种培育及对我国肉牛育种的启示[J]. 吉林农业大学学报, 2023, 45(4): 385-390.
ZHANG T L, WANG Z Z, ZHU B, et al. Cultivation of new Huaxi cattle varieties and its enlightenment to beef cattle breeding in China[J]. Journal of Jilin Agricultural University, 2023, 45(4): 385-390.
[46] 赵光平, 毛红霞, 杨树猛, 等. 阿什旦牦牛在甘南地区的适应性观察[J]. 畜牧兽医杂志, 2024, 43(5): 37-39.
ZHAO G P, MAO H X, YANG S M, et al. Adaptability observation of ashdan yak in Gannan[J]. Journal of Animal Science and Veterinary Medicine, 2024, 43(5): 37-39.
[47] 唐士杰. 天华肉羊新类群四世代羊生长和肉用性能的研究[D]. 兰州: 兰州大学, 2023.
TANG S J. Research on the growth and meat performance of four generations of Tianhua sheep new group[D]. Lanzhou: Lanzhou University, 2023.
[48] 杨洁. 华蒙肉羊与亲本杜泊羊、小尾寒羊肉品质差异分析[D]. 呼和浩特: 内蒙古农业大学, 2025.
YANG J. Analysis of meat quality differences between Huameng mutton sheep and their parents Dorper sheep and Small Tail Han sheep[D]. Hohhot: Inner Mongolia Agricultural University, 2025.
[49] 赵金艳, 权凯, 张子军, 等. 黄淮肉羊肉用性能的研究[J]. 内蒙古农业大学学报(自然科学版), 2021, 42(5): 59-64.
ZHAO J Y, QUAN K, ZHANG Z J, et al. Mutton performance of Huang-Huai sheep[J]. Journal of Inner Mongolia Agricultural University (Natural Science Edition), 2021, 42(5): 59-64.
[50] 张年, 索效军, 杨前平, 等. 湖北黑头羊母羊繁殖性能测定[J]. 黑龙江畜牧兽医, 2018(12): 77-80.
ZHANG N, SUO X J, YANG Q P, et al. Determination of reproductive performance of Hubei black-headed sheep and ewe[J]. Heilongjiang Animal Science and Veterinary Medicine, 2018(12): 77-80.
[51] 刘宝栋. 杜蒙羊早期生长性状遗传参数估计的研究[D]. 呼和浩特: 内蒙古农业大学, 2024.
LIU B D. Study on genetic parameter estimation of early growth traits of Dumeng sheep[D]. Hohhot: Inner Mongolia Agricultural University, 2024.
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