摘要： 动物免疫球蛋白的基因序列、结构类型、功能以及其多样性的机制一直国内外学者关注焦点。目前对于免疫球蛋白基因及其多样性表达机制的研究多数是以人类或者小鼠为对象,该文将论述猪、牛、羊、骆驼和家兔的免疫球蛋白基因结构及其表达机制,探究不同哺乳动物免疫球蛋白基因表达的特点,以期为动物免疫方面和抗病育种的研究提供参考。
| [1] Butler J E, Zhao Y, Sinkora M, et al.Immunoglobulins, antibody repertoire and B cell development[J]. Dev Comp Immunol, 2009, 33(3):321-333. [2] Woof J M.Immunoglobulins and their receptors, and subversion of their protective roles by bacterial pathogens[J]. Biochem Soc Trans, 2016, 44(6):1651-1658. [3] Guerrero A D, Moyes J S, Cooper L J.The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors[J]. Chin J Cancer, 2014, 33(9):421-433. [4] Ekman A, Pessa-Morikawa T, Liljavirta J, et al.B-cell development in bovine fetuses proceeds via a pre-B like cell in bone marrow and lymph nodes[J]. Dev Comp Immunol, 2010, 34(8):896-903. [5] Ekman A, Ilves M, Iivanainen A.B lymphopoiesis is characterized by pre-B cell marker gene expression in fetal cattle and declines in adults[J]. Dev Comp Immunol, 2012, 37(1):39-49. [6] Muyldermans S.Nanobodies: natural single-domain antibodies[J]. Annu Rev Biochem, 2013, 82:775-797. [7] Greenberg A S, Avila D, Hughes M, et al.A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks[J]. Nature, 1995, 374(6518):168-173. [8] Butler J E, Wertz N.The porcine antibody repertoire: variations on the textbook theme[J]. Front Immunol, 2012,3:153. [9] Butler J E, Sun X, Wertz N, et al.Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development[J]. Mol Immunol, 2011, 49(3):483-494. [10] Eguchi-Ogawa T, Wertz N, Sun X Z, et al.Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable heavy chain gene usage and the genomic organization of the variable heavy chain locus[J]. J Immunol, 2010, 184(7):3734-3742. [11] Butler J E, Wertz N, Deschacht N, et al.Porcine IgG: structure, genetics, and evolution[J]. Immunogenetics, 2009, 61(3):209-230. [12] Sun J, Butler J E.Molecular characterization of VDJ transcripts from a newborn piglet[J]. Immunology, 1996, 88(3):331-339. [13] Arun S S, Breuer W, Hermanns W.Immunohistochemical examination of light-chain expression (lambda/kappa ratio) in canine, feline, equine, bovine and porcine plasma cells[J]. Zentralbl Veterinarmed A, 1996, 43(9):573-576. [14] Schwartz J C, Lefranc M P, Murtaugh M P.Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus[J]. Immunogenetics, 2012, 64(5):399-407. [15] Schwartz J C, Lefranc M P, Murtaugh M P.Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion[J]. Immunogenetics, 2012, 64(4):303-311. [16] Briney B S, Crowe J J.Secondary mechanisms of diversification in the human antibody repertoire[J]. Front Immunol, 2013, 4:42. [17] Longerich S, Tanaka A, Bozek G, et al.The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions[J]. J Exp Med, 2005, 202(10):1443-1454. [18] Zhao Y, Kacskovics I, Rabbani H, et al.Physical mapping of the bovine immunoglobulin heavy chain constant region gene locus[J]. J Biol Chem, 2003, 278(37):35024-35032. [19] Schroeder H J.Similarity and divergence in the development and expression of the mouse and human antibody repertoires[J]. Dev Comp Immunol, 2006, 30(1-2):119-135. [20] Zhao Y, Kacskovics I, Pan Q, et al.Artiodactyl IgD: the missing link[J]. J Immunol, 2002, 169(8):4408-4416. [21] Aitken R, Hosseini A, MacDuff R. Structure and diversification of the bovine immunoglobulin repertoire[J]. Vet Immunol Im-munopathol, 1999, 72(1-2):21-29. [22] Hosseini A, Campbell G, Prorocic M, et al.Duplicated copies of the bovine JH locus contribute to the Ig repertoire[J]. Int Immunol, 2004, 16(6):843-852. [23] Ma L, Qin T, Chu D, et al.Internal Duplications of DH, JH, and C Region Genes Create an Unusual IgH Gene Locus in Cattle[J]. J Immunol, 2016, 196(10):4358-4366. [24] Almagro J C, Hernandez I, Ramirez M C, et al.Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications[J]. Immunogenetics, 1998, 47(5):355-363. [25] Chen L, Li M, Li Q, et al.Characterization of the bovine im-munoglobulin lambda light chain constant IGLC genes[J]. Vet Im-munol Immunopathol, 2008, 124(3-4):284-294. [26] Pasman Y, Saini S S, Smith E, et al.Organization and genomic complexity of bovine lambda-light chain gene locus[J]. Vet Im-munol Immunopathol, 2010, 135(3-4):306-313. [27] Koti M, Kataeva G, Kaushik A K.Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies[J]. Mol Immunol, 2010, 47(11-12):2119-2128. [28] Sok D, Le K M, Vadnais M L, et al.Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows[J]. Na-ture, 2017, 548(7665):108. [29] Hein W R, Dudler L.Diversification of sheep immunoglobulins[J]. Vet Immunol Immunopathol, 1999, 72(1-2):17-20. [30] Dufour V, Malinge S, Nau F.The sheep Ig variable region reper-toire consists of a single VH family[J]. J Immunol, 1996, 156(6):2163-2170. [31] Reynaud C A, Dufour V, Weill J C.Generation of diversity in mammalian gut-associated lymphoid tissues: restricted V gene usage does not preclude complex V gene organization[J]. J Im-munol, 1997, 159(7):3093-3095. [32] Jeong Y, Osborne B A, Goldsby R A.Early Vlambda diversification in sheep[J]. Immunology, 2001, 103(1):26-34. [33] Gontier E, Ayrault O, Godet I, et al.Developmental progression of immunoglobulin heavy chain diversity in sheep[J]. Vet Im-munol Immunopathol, 2005, 103(1-2):31-51. [34] Yu X, Du L, Wu M, et al.The analysis of organization and diversity mechanism in goat immunoglobulin light chain gene loci[J]. Immunobiology, 2020, 225(2):151889. [35] 杜丽娟. 山羊胚系免疫球蛋白重链可变区基因座结构及多样性机制分析[D]. 西安:西北农林科技大学, 2016. [36] Du L, Wang S, Zhu Y, et al.Immunoglobulin heavy chain vari-able region analysis in dairy goats[J]. Immunobiology, 2018, 223(11):599-607. [37] Du L, Wang S, Zhu Y, et al.Immunoglobulin heavy chain vari-able region analysis in dairy goats[J]. Immunobiology, 2018, 223 (11):599-607. [38] Hamers-Casterman C, Atarhouch T, Muyldermans S, et al.Naturally occurring antibodies devoid of light chains[J]. Nature, 1993, 363(6428):446-448. [39] Muyldermans S.Nanobodies: natural single-domain antibodies[J]. Annu Rev Biochem, 2013,82:775-797. [40] Yuexing Liu L Y Y L. Characterization of heavy chain antibody gene repertoires in Bactrian camels[J]. J Genet Genomics, 2022, 50(1):38-45. [41] Lanning D K, Zhai S K, Knight K L.Analysis of the 3' Cmuegion of the rabbit Ig heavy chain locus[J]. Gene, 2003, 309(2):135-144. [42] Lefranc M P, Giudicelli V, Kaas Q, et al.IMGT, the international ImMunoGeneTics information system[J]. Nucleic Acids Res, 2005, 33(Database issue):D593-D597. [43] Ros F, Puels J, Reichenberger N, et al.Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus[J]. Gene, 2004, 330:49-59. |
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