中国畜禽种业 ›› 2022, Vol. 18 ›› Issue (10): 30-33.
魏著英, 白春玲, 杨磊, 苏广华, 武云喜, 张立, 李光鹏*
摘要： 在国家科技重大专项支持下,内蒙古大学牛遗传改良与生物育种技术团队历时15年,以蒙古牛、鲁西牛和西门塔尔牛为对象,通过CRISPR/Cas9基因编辑技术,对调控肌肉发育的抑肌基因（Myostatin,MSTN）进行编辑,成功培育出“双肌鲁西牛”等高产优质肉牛新品系。基因编辑牛的生长速度、体型外貌与产肉性能等均得到显著提高,突破了黄牛品种体型小、生长慢、产肉率低的肉用性状瓶颈,该文系统分析了基因编辑牛性状改善的生理学分子机制,有望成为可与国际优秀肉牛媲美的自主肉牛品种。
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