外源性抗氧化剂对卵母细胞体外成熟的影响

中国畜禽种业 ›› 2023, Vol. 19 ›› Issue (7): 114-120.

外源性抗氧化剂对卵母细胞体外成熟的影响

李一^1,2,3,4, 马述海^5#, 彭华⁶, 李存^1,*, 马毅^2,3,4,*

1.天津农学院动物科学与动物医学学院,天津 300384;
2.天津市农业科学院畜牧兽医研究所, 天津 300381;
3.天津市畜禽分子育种与生物技术重点实验室, 天津 300381;
4.天津市畜禽健康养殖工程技术中心, 天津300381;
5.天祝藏族自治县生产力促进中心,甘肃武威 733299;
6.中国农业科学院农业信息研究所,北京 100081

收稿日期:2023-01-23 出版日期:2023-07-26 发布日期:2023-07-24
通讯作者: ^*马毅（1976—）,男,甘肃平凉人,研究员,硕士生导师,研究方向：动物遗传育种与繁殖,E-mail：tjnnyz@126.com;李存（1971—）,男,河北磁县人,教授,硕士生导师,研究方向：兽医药理学与毒理学,E-mail：hhlicun@163.com。
作者简介:李一（1998—）,女,河北唐山人,硕士研究生,研究方向：动物遗传育种与繁殖,E-mail：1826465446@qq.com。^#共同第一作者马述海（1970—）,男,农艺师,研究方向：农业生产,E-mail：840359655@qq.com。
基金资助:
甘肃省重点研发计划——农业类（21YF5NP208）; 天津市农业科学院种业自主创新专项资助（2022ZYCX010）; 2022年度东西部协作科技项目

Effects of Exogenous Antioxidants on in vitro Maturation of Oocytes

Li Yi^1,2,3,4, Ma Shuhai^5#, Peng Hua⁶, Li Cun^1,*, Ma Yi^2,3,4,*

1. College of Animal Science and veterinary Medicine, Tianjin Agricultural University, Tianjin 300384;
2. Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin 300381, China;
3. Tianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin 300381, China;
4. Tianjin Engineering Research Center of Animal Healthy Farming, Tianjin 300381, China;
5. Tianzhu Tibetan Autonomous County Productivity Promotion Center, Wuwei, 733299, Gansu;
6. Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing, 100081

Received:2023-01-23 Online:2023-07-26 Published:2023-07-24

摘要/Abstract

摘要： 该文综述了不同种类的抗氧化剂对体外受精的影响和一些天然抗氧化剂之间发生的协同作用。抗氧化剂能减轻或预防卵母细胞产生氧化应激导致DNA受损、酶失活、脂质过氧化、蛋白质的氧化变化、卵子纺锤体形态和染色体排布异常等作用。

关键词: 抗氧化剂, 卵母细胞成熟, 活性氧, 影响

Abstract: This paper reviews the effects of different antioxidants on IVF and the synergistic effects of some natural antioxidants. Antioxidants can reduce or prevent the oxidative stress of oocytes resulting in DNA damage, enzyme inactivation, lipid peroxidation, oxidative changes of proteins, egg spindle morphology and abnormal chromosome arrangement.

Key words: antioxidant, oocyte maturation, reactive oxygen species, influence

李一, 马述海, 彭华, 李存, 马毅. 外源性抗氧化剂对卵母细胞体外成熟的影响[J]. 中国畜禽种业, 2023, 19(7): 114-120.

Li Yi, Ma Shuhai, Peng Hua, Li Cun, Ma Yi. Effects of Exogenous Antioxidants on in vitro Maturation of Oocytes[J]. The Chinese Livestock and Poultry Breeding, 2023, 19(7): 114-120.

参考文献

[1] 彭巍, 黄荣, 舒适, 等. 褪黑素抑制氧化应激促进牦牛卵母细胞体外成熟的研究[J]. 青海畜牧兽医杂志, 2021, 51(3):1-6, 66.
[2] Cajas Y N, Canón-Beltrán K, Ladrón de Guevara M, et al. Antioxidant nobiletin enhances oocyte maturation and subsequent embryo development and quality[J]. Int J Mol Sci, 2020, 21(15):5340.
[3] Liang L F, Qi S T, Xian Y X, et al.Protective effect of antioxi-dants on the pre-maturation aging of mouse oocytes[J]. Sci Rep, 2017, 7(1):14
[4] Li Y, Dong Z, Liu S, et al.Astaxanthin improves the development of the follicles and oocytes through alleviating oxidative stress induced by BPA in cultured follicles[J]. Sci Rep, 2022, 12(1):7853.
[5] Piras A R, Menéndez-Blanco I, Soto-Heras S, et al.Resveratrol supplementation during in vitro maturation improves embryo development of prepubertal goat oocytes selected by brilliant cresyl blue staining[J]. J Reprod Dev, 2019,65(2):113-120.
[6] Gao W, Jin Y, Hao J, et al.Procyanidin B1 promotes in vitro maturation of pig oocytes by reducing oxidative stress[J]. Mol Reprod Dev, 2021, 88(1):55-66.
[7] 易疆莺, 滕文顶, 王芳, 等.抗氧化物原花青素对人未成熟卵母细胞体外成熟的影响[J]. 中国计划生育和妇产科, 2021, 13(10):82-86.
[8] Chen C C, Chan W H.Injurious effects of curcumin on maturation of mouse oocytes, fertilization and fetal development via apoptosis[J]. Int J Mol Sci, 2012, 13(4):4655-4672.
[9] 汪锋. 白藜芦醇和褪黑素对卵母细胞成熟及胚胎发育的作用机制[D]. 北京:中国农业大学, 2014.
[10] Han J, Wang H, Zhang T, et al.Resveratrol attenuates doxorubicin-induced meiotic failure through inhibiting oxidative stress and apoptosis in mouse oocytes[J]. Aging (Albany NY), 2020, 12(9):7717-7728.
[11] 刘美菊. 白藜芦醇在高龄小鼠和人卵母细胞成熟中的作用研究[D]. 泰安:山东大学, 2016.
[12] Li Y, Wang J, Zhang Z, et al.Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress[J]. J Anim Sci Biotechnol, 2016,7:33.
[13] Wang F, Tian X, Zhang L, et al.Beneficial effect of resveratrol on bovine oocyte maturation and subsequent embryonic development after in vitro fertilization[J]. Fertil Steril, 2014, 101(2):577-586.
[14] Piras A R, Menéndez-Blanco I, Soto-Heras S, et al.Resveratrol supplementation during in vitro maturation improves embryo development of prepubertal goat oocytes selected by brilliant cresyl blue staining[J]. J Reprod Dev, 2019, 65(2):113-120.
[15] Mukherjee A, Malik H, Saha A P, et al.Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand-made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression[J]. J Assist Reprod Genet, 2014,31(2):229-239.
[16] Zhou C, Zhang X, ShiYang X, et al. Tea polyphenol protects against cisplatin-induced meiotic defects in porcine oocytes[J]. Aging (Albany NY), 2019, 11(13):4706-4719.
[17] Huang Z, Pang Y, Hao H, et al.Effects of epigallocatechin-3-gal-late on bovine oocytes matured in vitro[J]. Asian-Australas J Anim Sci, 2018, 31(9):1420-1430.
[18] Huang K, Li C, Gao F, et al.Epigallocatechin-3-gallate promotes the in vitro maturation and embryo development following IVF of porcine oocytes[J]. Drug Des Devel Ther, 2021, 15:1013-1020.
[19] 陈雪. 维生素A对猪卵母细胞成熟及胚胎早期发育的影响[D].长春:吉林大学, 2020.
[20] Saadeldin I M, Swelum A A, Elsafadi M, et al.Effects of all-trans retinoic acid on the in vitro maturation of camel (Camelus dromedarius) cumulus-oocyte complexes[J]. J Reprod Dev, 2019, 65(3):215-221.
[21] Gad A, Abu Hamed S, Khalifa M, et al.Retinoic acid improves maturation rate and upregulates the expression of antioxidant-related genes in vitro matured buffalo (Bubalus bubalis) oocytes[J]. Int J Vet Sci Med, 2018, 6(2):279-285.
[22] Yu X X, Liu Y H, Liu X M, et al.Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes[J]. Sci Rep, 2018, 8(1):6132.
[23] Zhang X, Zhou C, Li W, et al.Vitamin C protects porcine oocytes from microcystin-LR toxicity during maturation[J]. Front Cell Dev Biol, 2020, 8:582715.
[24] Karimian M, Zandi M, Sanjabi M R, et al.Effects of grape seed extract, quercetin and vitamin C on ovine oocyte maturation and subsequent embryonic development[J]. Cell Mol Biol (Noisy-le-grand), 2018, 64(4):98-102.
[25] Natarajan R, Shankar M B, Munuswamy D.Effect of α-tocopherol supplementation on in vitro maturation of sheep oocytes and in vitro development of preimplantation sheep embryos to the blastocyst stage[J]. J Assist Reprod Genet, 2010, 27(8):483-490.
[26] Sidi S, Pascottini O B, Angel-Velez D, et al.Lycopene supplementation to serum-free maturation medium improves in vitro bovine embryo development and quality and modulates embryonic transcriptomic profile[J]. Antioxidants (Basel), 2022, 11(2):344.
[27] Cao Y, Zhao H, Wang Z, et al.Quercetin promotes in vitro matu-ration of oocytes from humans and aged mice[J]. Cell Death Dis, 2020,11(11):965.
[28] Cajas Y N, Canón-Beltrán K, Ladrón de Guevara M, et al. Antioxidant nobiletin enhances oocyte maturation and subsequent embryo development and quality[J]. Int J Mol Sci, 2020, 21(15):5340.
[29] 胡慧茹, 王健, 张柳明, 等. 褪黑素对高龄小鼠卵母细胞体外成熟的影响[J]. 中国兽医科学, 2021, 51(2):251-256.
[30] Azandeh S, Moghadam M T, Rashno M, et al.The effect of different doses of melatonin on in vitro maturation of human follicular fluid-derived oocyte-like cells[J]. JBRA Assist Reprod, 2022, 26(2):288-298.
[31] 李亚男, 刘恋, 李冰玉, 等. 褪黑素调控SIRT3对糖尿病脑缺血再灌注损伤小鼠脑组织线粒体的保护作用[J]. 山东医药, 2022, 62(20):20-23.
[32] 白欣洁, 刘莎莎, 王功民, 等. 褪黑素在雌性动物繁殖中的调控作用[J]. 中国兽医科学, 2020, 50(7):908-914.
[33] Ma W, Wu H, Li G, et al.Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora[J]. Front Endocrinol (Lausanne), 2022, 13:966120.
[34] Park H J, Park S Y, Kim J W, et al.Melatonin improves oocyte maturation and mitochondrial functions by reducing bisphenol A-derived superoxide in porcine oocytes in vitro[J]. Int J Mol Sci, 2018, 19(11):3422.
[35] Nikmard F, Hosseini E, Bakhtiyari M, et al.The boosting effects of melatonin on the expression of related genes to oocyte maturation and antioxidant pathways: a polycystic ovary syndrome- mouse model[J]. J Ovarian Res, 2022, 15(1):11.
[36] Tian X, Wang F, Zhang L, et al.Beneficial effects of melatonin on the in vitro maturation of sheep oocytes and its relation to melatonin receptors[J]. Int J Mol Sci, 2017, 18(4):834.
[37] Chen Y,Shan X, Jiang H, et al.Exogenous melatonin directly and indirectly influences sheep oocytes[J]. Front Vet Sci, 2022, 9:903195.
[38] 彭巍. 牦牛冷暖季卵巢差异分析及添加褪黑素对牦牛卵母细胞体外成熟、胚胎体外发育的影响[D]. 西安:西北农林科技大学, 2019.
[39] 孙叶清. 褪黑素对牛精液品质、卵母细胞体外成熟及体外发育能力影响的研究[D]. 兰州:甘肃农业大学, 2016.
[40] Park H J, Park J Y, Kim J W, et al.Melatonin improves the meiotic maturation of porcine oocytes by reducing endoplasmic reticulum stress during in vitro maturation[J]. J Pineal Res, 2018, 64(2):e12458.
[41] 孙铭菊, 屈佳丹, 郇延军. 外源因子调控卵母细胞体外成熟的研究进展[J]. 中国畜牧杂志, 2022, 58(9):52-57.
[42] 潘红梅, 臧胜芹, 张亮, 等. 外源性褪黑素促进哺乳动物卵母细胞成熟的研究进展[J]. 中国畜牧杂志, 2021, 57(12):25-30.
[43] 张通, 高鹏, 李国良, 等. 外源褪黑素对羔羊卵母细胞成熟及卵丘扩展相关基因表达的影响[J]. 山西大同大学学报(自然科学版), 2021, 37(2):57-61, 101.
[44] 李悦. 褪黑素和生长激素对人类卵母细胞成熟及早期胚胎发育的作用研究[D]. 泰安:山东大学, 2020.
[45] 艾日夏提·地里夏提, 周正娜, 张也, 等.藏红花素对小鼠卵母细胞体外成熟能力的影响[J]. 中国畜牧兽医, 2021, 48(10):3734-3740.
[46] 玄彪. 藏红花素对猪卵母细胞成熟过程中抗氧化性和卵裂率的影响[D]. 延吉:延边大学, 2018.
[47] 盛雪飞, 彭燕, 陈健初. 天然抗氧化剂之间的协同作用研究进展[J]. 食品工业科技, 2010, 31(7):414-417, 421.
[48] 张凌云. 褪黑素和绿茶多酚EGCG协同抑癌研究[D]. 合肥:安徽农业大学, 2018.
[49] 王东旭. 褪黑素保护高剂量EGCG引起的小鼠肝毒性及其分子机制[D]. 合肥:安徽农业大学, 2015.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed