中国畜禽种业 ›› 2022, Vol. 18 ›› Issue (11): 3-8.

• 综述 • 上一篇    下一篇

黄曲霉毒素B1对动物危害作用研究

马浩海, 袁正宁, 刘静, 张西锋*   

  1. 青岛农业大学动物医学院,山东青岛 266109
  • 出版日期:2022-11-26 发布日期:2022-12-28
  • 通讯作者: *张西锋(1977—),男,山东郓城人,教授,主要从事动物生殖生理与生殖调控研究工作。
  • 作者简介:马浩海(1997—),男,山东淄博人,研究生。

  • Online:2022-11-26 Published:2022-12-28

摘要: 黄曲霉毒素是一类强毒性的真菌毒素。该文综述了黄曲霉毒素的概述、理化性质、对畜禽机体和雄性生殖生理的毒性作用,以及黄曲霉毒素B1的检测和脱毒技术,以期为黄曲霉毒素防治措施提供参考。

关键词: 黄曲霉毒素, AFB1, 动物, 细胞

[1] Cotty PJ, Bhatnagar D.Variability among atoxigenic Aspergillus flavus strains in ability to prevent aflatoxin contamination and production of aflatoxin biosynthetic pathway enzymes[J]. Applied & Environmental Microbiology, 1994, 60(7):2248-2251.
[2] Kurtzman CP, Horn BW, Hesseltine CW.Aspergillus nomius, a new aflatoxin-producing species related to Aspergillus flavus and Aspergillus tamarii[J]. Antonie van Leeuwenhoek, 1987, 53(3):147-158.
[3] 李俊霞, 梁志宏, 关舒, 等. 黄曲霉毒素B1降解菌株的筛选及鉴定[J]. 中国农业科学, 2008(5):1459-1463.
[4] 李超波. 黄曲霉毒素B1降解菌的分离鉴定及其降解特性[D]. 南昌:南昌大学, 2012.
[5] 陈建民, 张雪辉. 食品和饲料中黄曲霉毒素概述[J].粮食与油脂, 2004(3):41-42.
[6] 劳文艳, 林素珍. 黄曲霉毒素对食品的污染及危害[J]. 北京联合大学学报(自然科学版), 2011, 25(1):64-69.
[7] Khan R, Ghazali FM, Mahyudin NA, et al.Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review[J]. Journal of Fungi-Open Access Mycology Journal, 2021, 7(8):606.
[8] Ueng YF, Shimada T, Yamazaki H, Peterguengerich F.Aflatoxin B1 oxidation by human cytochrome P450s[J]. The Journal of Toxicological Sciences, 1998, 23:132-135.
[9] Swenson DH, Lin JK, Miller EC, et al.Aflatoxin B1-2,3-oxide as a Probable Intermediate in the Covalent Binding of Aflatoxins B1 and B2 to Rat Liver DNA and Ribosomal RNA in Vivo[J]. Cancer Research, 1977, 37(1):172-181.
[10] Tong WM, Lee MK, Galendo D, et al.Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice[J]. International Journal of Cancer, 2010, 119(4):745-749.
[11] 吴丹. 黄曲霉毒素在粮食和食品中的危害及防治[J]. 粮食加工, 2007(3):91-94.
[12] 宫春波, 姜连芳, 张永翠, 等. 黄曲霉毒素在食品中的危害及去除方法[J]. 食品研究与开发, 2004(1):120-123.
[13] Li X, Lv Z, Chen J, et al.Bacillus amyloliquefaciens B10 can alleviate liver apoptosis and oxidative stress induced by aflatoxin B1[J]. Food and Chemical Toxicology, 2021, 151:112124.
[14] Zhou H, Wang J, Ma L, et al.Oxidative DNA damage and multi-organ pathologies in male mice subchronically treated with aflatoxin B1[J]. Ecotoxicology and Environmental Safety, 2019, 186:109697.
[15] Xu F, Li Y, Cao Z, et al.AFB1-induced mice liver injury involves mitochondrial dysfunction mediated by mitochondrial biogenesis inhibition[J]. Ecotoxicology and Environmental Safety, 2021, 216(12):112213.
[16] Slizewska K, Cukrowska B, Smulikowska S, et al.The Effect of Probiotic Supplementation on Performance and the Histopathological Changes in Liver and Kidneys in Broiler Chickens Fed Diets with Aflatoxin B1[J]. Toxins (Basel). 2019,11(2):112.
[17] Hassan AA, Hafsa SHA, Elghandour MMMY, et al.Dietary Supplementation with sodium bentonite and coumarin alleviates the toxicity of aflatoxin B1 in rabbits-ScienceDirect[J]. Toxicon, 2019, 171:35-42.
[18] Tessari ENC, Oliveira CAF, Cardoso ALSP, et al.Effects of aflatoxin B1 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks[J]. British Poultry Science, 2006, 47(3):357-364.
[19] 赵晔琪. 解淀粉芽孢杆菌B10对黄曲霉毒素B1诱导的小鼠肾脏损伤的保护作用研究[D]. 沈阳:沈阳农业大学, 2020.
[20] Park S, Lee JY, You S, et al.Neurotoxic effects of aflatoxin B1 on human astrocytes in vitro and on glial cell development in zebrafish in vivo[J] J Hazard Mater, 2020, 386:121639.
[21] Abdel-Aziem SH, Hassan AM, Abdel-Wahhab MA.Dietary supplementation with whey protein and ginseng extract counteracts oxidative stress and DNA damage in rats fed an aflatoxin-contaminated diet[J]. Mutat Res, 2011, 723:65-71.
[22] Rotimi OA, Onuzulu CD, Dewald AL, et al.Early Life Exposure to Aflatoxin B1 in Rats: Alterations in Lipids, Hormones, and DNA Methylation among the Offspring[J]. International Journal of Environmental Research and Public Health, 2021, 18(2):589.
[23] Zimmermann E, Berentzen TL, Gamborg M, et al.Sex-specific associations between birth weight and adult primary liver cancer in a large cohort of Danish children[J]. International Journal Cancer, 2016, 138(6):1410-1415.
[24] Liu J, Wang QC, Han J, et al.Aflatoxin B1 is toxic to porcine oocyte maturation[J]. Mutagenesis, 2015, 30(4):527-535.
[25] Jiang Y, Hansen PJ, Xiao Y, et al.Aflatoxin compromises development of the preimplantation bovine embryo through mechanisms independent of reactive oxygen production[J]. Journal of Dairy Science, 2019, 102(11):10506-10513.
[26] Uriah N, Ibeh IN, Oluwafemi F, et al.LABORATORY REPORT - A Study on the Impact of Aflatoxin on Human Reproduction[J]. African Journal of Reproductive Health, 2001, 5(1):106-110.
[27] Clermont Y.Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal[J]. Physiological Reviews, 1972, 52(1):198-236.
[28] 熊博辉. LncRNA8276调节小鼠精子发生的机制研究[D]. 青岛:青岛农业大学, 2021.
[29] Zhou R, Wu J, Liu B, et al.The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis[J]. Cellular and Molecular Life Sciences, 2019, 76(14):2681-2695
[30] Nie X, Munyoki SK, Sukhwani M, et al.Single-cell analysis of human testis aging and correlation with elevated body mass index[J]. Developmental Cell, 2022. 57(9):1160-1176.
[31] 何光勇, 罗兰. 睾丸结构和功能异常的常见影响因素[J].云南大学学报(自然科学版), 2019, 41(S1):97-102.
[32] Zamir-Nasta Z, Razi M, Shapour H, et al.Roles of p21, p53, cyclin D1, CDK-4, estrogen receptor in aflatoxin B1-induced cytotoxicity in testicular tissue of mice[J]. Environmental Toxicology, 2018, 33(3-4):385-395.
[33] Owumi SE, Otunla MT, Arunsi UO, et al.Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis[J]. Exp Biol Med (Maywood), 2022:15353702221098060.
[34] Ashraf A, Saleemi MK, Mohsin M, et al.Pathological effects of graded doses of aflatoxin B1 on the development of the testes in juvenile white leghorn males[J]. Environmental Science and Pollution Research,2022:1-10.
[35] Lin LX, Cao QQ, Zhang CD, et al.Aflatoxin B1 causes oxidative stress and apoptosis in sheep testes associated with disrupting rumen microbiota[J]. Ecotoxicology and Environmental Safety, 2022, 232:113225.
[36] Devegowda G, Murthy T.Mycotoxins: Their effects in poultry and some practical solutions[J]. mycotoxin blue book, 2005:25-56.
[37] Egmond HPV, Jonker MA.Worldwide Regulations on Aflatoxins—The Situation in 2002[J]. Journal of Toxicology: Toxin Reviews, 2004, 23(2-3):273-293.
[38] Pereira CS, Cunha SC, José O.Fernandes. Prevalent Mycotoxins in Animal Feed: Occurrence and Analytical Methods[J]. Toxins, 2019, 11(5):290.
[39] Zhang X, Eremin SA, Wen K, et al.Fluorescence Polarization Immunoassay Based on a New Monoclonal Antibody for the Detection of the Zearalenone Class of Mycotoxins in Maize[J]. Journal of Agricultural & Food Chemistry, 2017, 65(10):2240-2247.
[40] 马良. 黄曲霉毒素B1高灵敏度检测技术研究[D]. 北京:中国农业科学院, 2007.
[41] Alshannaq A, Yu JH. Occurrence, Toxicity,Analysis of Major Mycotoxins in Food[J]. International Journal of Environmental Research and Public Health, 2017, 14(6):632.
[42] Pereira VL, Fernandes JO, Cunha SC.Mycotoxins in cereals and related foodstuffs: A review on occurrence and recent methods of analysis[J]. Trends in Food Science & Technology, 2014, 36(2):96-136.
[43] Shephard GS.Current Status of Mycotoxin Analysis: A Critical Review[J]. Journal of Aoac International, 2016, 99(4):842-848.
[44] Tothill I.Biosensors and nanomaterials and their application for mycotoxin determination[J]. World Mycotoxin Journal, 2011, 4(4):361-374.
[45] Xue Z, Zhang Y, Yu W, et al.Recent advances in aflatoxin B1 detection based on nanotechnology and nanomaterials-A review[J]. Analytica Chimica Acta, 2019, 1069:1-27.
[46] Pereira CS, Cunha SC, José O.Fernandes. Prevalent Mycotoxins in Animal Feed: Occurrence and Analytical Methods[J]. Toxins, 2019, 11(5):290.
[47] Rushing BR, Selim MI.Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods[J]. Food and Chemical Toxicology, 2019, 124:81-100.
[48] Arzandeh S, Jinap S.Effect of initial aflatoxin concentration, heating time and roasting temperature on aflatoxin reduction in contaminated peanuts and process optimisation using response surface modelling[J]. International Journal of Food Science & Technology, 2011, 46(3):485-491.
[49] Prado G, Carvalho EP, Oliveira MS, et al.Effect of gamma-irradiation (60Co) on aflatoxin B1 inactivation in peanut (Arachis hypogaea L.). 2005,64(2): 186-192.
[50] 叶盛群. 腐殖酸钠去除霉菌毒素效果的研究[D]. 雅安:四川农业大学, 2009.
[51] Savi GD, Piacentini KC, Scussel VM.Ozone Treatment Efficiency in Aspergillus and Penicillium Growth Inhibition and Mycotoxin Degradation of Stored Wheat Grains (Triticum aestivumL.)[J]. Journal of Food Processing and Preservation, 2015, 39(6):940-948.
[52] Qian Z, Ke X, Tatsumi E, et al.Elimination of aflatoxin B 1 in peanuts by acidic electrolyzed oxidizing water[J]. Food Control, 2012, 27(1):16-20.
[53] Burgos-Hernández A, Price RL, Jorgensen-Kornman K, et al.Decontamination of aflatoxin B1-contaminated corn by ammonium persulphate during fermentation[J]. Journal of the Science of Food and Agriculture, 2002, 82(5):546-552.
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